Advances in Biomedical Engineering. Volume 6 by J.H.U. Brown, James Francis Dickson

By J.H.U. Brown, James Francis Dickson

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Measurement system of Yamashiro et al. (1975). 1667 t (min) FIG. 13. Estimated impulse response function for normal subject. 38 GEORGE A. BEKEY AND STANLEY M. YAMASHIRO rate constant λ. Then the mean rate constant I is I = £ ° Xg(X) dk=- df(t)/dt\,=o (97) and the mean-squared rate constant λ2 is Jl = So λ^{λ) άλ = d2 /W/& 2 | t = o (98 > Since —df(t)/dt corresponds to the impulse response function, evaluating the impulse response function or its derivative at t = 0 yields the first two moments describing the distribution function of lung rate constants.

90) (91) (1 + an) _. za2 sO-^-innsp (92) 36 GEORGE A. BEKEY AND STANLEY M. YAMASHIRO If we let D = (d2/dn2){ln H{n)\ then D = za2/(l + an)2 (93) 1/D = (1 + anf/za2 1 yJD 1 4- an ayjz 1 ayjz (94) n ^z /Λ_ Equation (95) represents a linear equation for the regression l/y/D on n with l/y/z as the slope and l/a^fzas the intercept. From this regression, parameters a and z can be estimated. By rearranging Eq. (90), In H(n) + z ln(l + an) = In H(0) - sn The left-hand side of the equation can be evaluated for each n, given the values of a and z, and another regression can be used to estimate H(0) and s.

1971). Simulation 17, 197-2-5. Yamashiro, S. , Maloney, J. C , Daubenspeck, J. , and Karuza, S. K. (1975). Proc. Hawaii Int. Conf. Syst. , 8th, 1975 pp. 169-170. Integrated Electronics in Medicine JAMES D. MEINDL Department of Electrical Engineering Stanford University Stanford, California I. Introduction II. Integrated Circuit Technology III. Subcutaneous Electronics A. Monitoring Systems B. Therapeutic and Prosthetic Systems IV. Supercutaneous Electronics A. Monitoring and Telemetry Systems B.

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