Advances in Pain Therapy I by Michael J. Cousins (auth.), J. Chrubasik M.D., E. Martin

By Michael J. Cousins (auth.), J. Chrubasik M.D., E. Martin M.D., M. Cousins M.D. (eds.)

Since 1961, while ache treatment used to be brought through Bonica, the- re were world-wide efforts to set up simple regimens for the therapy of power soreness. but many sufferers nonetheless proceed to be afflicted by intractable soreness regardless of the availa- bility of potent therapy that might enormously enhance their caliber of existence. the inability of experts accustomed to fresh advancements is among the motives. there's con- sequently an outstanding call for for interdisciplinary soreness clinics and professional education courses. This publication constitutes either a invaluable advent and an outline of present simple regimens and the newest subtle innovations in soreness therapy.

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Plummer JL, Cherry DA, Cousins MJ, Gourlay GK, Onley MM, Evans KHA (1991) Long-term spinal administration of morphine in cancer and non-cancer pain: a retrospective study. Pain 44:215-220 53. Richter W, Barth H, Flohe L, Giertz H (1985) Klinische Untersuchung zur Abhiingigkeitsentwicklung bei oraler Therapie mit Tramadol. Drug Res 35:1742-1744 54. Samuelsson H, Hedner T (1991) Pain characterization in cancer patients and the analgesic response to epidural morphine. Pain 46:3-8 55. Shetter AG, Hadley MN, Wilkinson E (1986) Administration of intraspinal morphine sulfate for the treatment of intractable cancer pain.

Lancet 2: 1208-1209 14. Chrubasik J, Scholler KL, Wiemers K, Weigel K, Friedrich G (1984) Low-dose infusion of morphine prevents respiratory depression. Lancet 1 :793 15. Chrubasik J, Falke KF, Zindler M, Volk B, Blond S, Meynadier J (1986) Is calcitonin an analgesic agent? Pain 27:273-276 16. CIllubasik J, Vogel W, Trotschler, H, Farthmann EH (1987) Continuous-plus-ondemand epidural infusion of buprenorphine versus morphine' in postoperative treatment of pain. Drug Res 37:361-363 17. Chrubasik J, Warth L, WUst H, Bretschneider H, Schulte-Monting J, Roher HD, Zindler M (1988) Wirksamkeit peridural applizierten Tramadols bei der Behandlung von Schmerzen nach abdominalchirurgischen Eingriffen.

Pain~ Duration of treatment (days)" 49 (7-397) 65 (7-283) 47 (7-420) 48 (7-443) 54/19 (6-129/3-47) 96/155 (1-1215)/? (21-501) CNMP, chronic non-malignant pain. Ref. [8] [22] [25] [29] [42] [52] [58] Spinal Opioid Treatment for Chronic Pain: An Update 25 In light of the short mean observation periods of about 3 months under epidural morphine and 6 months under intrathecal morphine, the failure rate of spinal opioid treatment due to technical problems and adverse effects may even be higher with longer treatment periods.

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