Antihypertensive Therapy: Principles and Practice an by C. Bartorelli (auth.), F. Gross (eds.)

By C. Bartorelli (auth.), F. Gross (eds.)

Hypertension has definitely been one of many issues so much fre­ quently mentioned at symposia, conferences, and congresses in the course of contemporary years. there's a number of purposes for this; 3 of them are visible: to start with, the truth that a wide percentage of the world's inhabitants is being affected by quite a few kinds of hypertensive disorder; secondly, expanding wisdom of the pathogenesis of high blood pressure and of the disturbances underlying it; and, thirdly, the marked development which has been made in antihypertensive remedy during the last fifteen years. while plans for the current symposium have been being drawn up, it was once felt that it's going to now not easily bring about simply one other assembly on high blood pressure, yet may still position specific emphasis on these features which had no longer been competently mentioned at earlier symposia of this type. interestingly sufficient, the subject which seemed to have acquired least awareness some time past was once treatment, even though from the sensible perspective this is often by means of a long way crucial. the alternative of treatment because the major topic of the complete symposium additionally looked to be warranted in view of the rather lengthy interval that had elapsed seeing that potent antihyper­ tensive therapy grew to become on hand; the time had in truth come now to judge the advantages in addition to the shortcomings of drug remedy as on hand today.

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Antihypertensive Therapy: Principles and Practice an International Symposium

High blood pressure has definitely been one of many subject matters such a lot fre­ quently mentioned at symposia, conferences, and congresses in the course of contemporary years. there is numerous purposes for this; 3 of them are seen: to start with, the truth that a wide share of the world's inhabitants is being affected by a variety of different types of hypertensive affliction; secondly, expanding wisdom of the pathogenesis of high blood pressure and of the disturbances underlying it; and, thirdly, the marked growth which has been made in antihypertensive remedy over the last fifteen years.

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Pharmacol. Meeting, Prague, 1963. Ed. by K. K. CHEN and B. MUKERJI. Czechoslovac Medical Press, Prague, 1965, 7, p. BEIN, H. , P. A. DESAULLES, and P. LoUSTALOT: Experientia 13, 130 (1957). - BEIN, H. , F. GROSS, J. TRn>OD, and R. MEIER: Schweiz. med. Wschr. 83, 336 (1953). - BENFEY, B. , and D. R. : Brit. J. Pharmacol. 22, 366 (1964). , P. R. HEDWALL, and M. MEIER: Experientia 21, 136 (1965a). , P. R. HEDWALL, and M. MEIER: Experientia 21, 231 (1965b). , and M. LINDQVIST: 28 H. J. BEIN and H. BRUNNER: Mode of action of antihypertensive drugs Acta physiol.

A possible distal effect of the thiazide diuretics has been postulated to contribute to their antidiuretic activity, which will be discussed below. , 1964). Under the influence of the drug, TcH • o falls to zero: an isotonic urine is excreted by the kidneys of dehydrated animals. Although up to now these effects have apparently always proved reversible, a drug with such an action certainly cannot be considered innocuous. Suppression of urinary concentrating ability and even minimal disturbances in the elaboration of a hypotonic urine point to an impairment of the counter-current multiplier system thought to be responsible for the Pharmacology of diuretics 43 high osmolarity of interstitial fluid in the renal papilla.

Table 3. Effect 0 BaCi. /ml. Reserpine. Hydralazine. Gulnea·plg ileum Histamine Table 2. , 1956) co ..... I ~. 1 ~ a t a ~ g. 20 H. J. BEIN and H. BRUNNER: an increase in cardiac output and heart rate. AHLQUIST et a!. (1947) with regard to tolazoIine and by MAXWELL et a!. (1958) with regard to the ganglionic blocking agent, chlorisondamine. The latter authors analysed in various species, including monkey, dog, rabbit, and rat, the compensatory mechanisms to chlorisondamine. They present evidence indicating that barbiturates interfere with compensatory mechanisms which normally function in the normotensive dog and rat; these mechanisms appear to be less predominant in the monkey and in the rabbit.

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